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DNA Vaccines
New findings in DNA vaccines described from Fourth Military Medical University
August 6th, 2008
According to a study from Xian, People's Republic of China, "Genetic immunity is a new promising approach for the development of novel tuberculosis vaccines. In this study, it is shown that DNA vaccines expressing the fusion protein of antigen 85B (Ag85B) and early secreted antigenic target 6-kDa antigen (ESAT6) can induce high levels of specific IgG2a antibody subtype in the mice." "With the prolongation of postimmunization time, the levels of IgG2a antibody decrease gradually. Although a high-level specific IgG2a antibody subtype is also elicited by classical BCG, the ratio of antibody subtypes IgG2a to IgG1 changes 4weeks after immunization, and IgG1 is gradually...
Source: Vaccine Weekly (2008-08-06)
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