Vaccine Weekly
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Hepatitis B Virus
Reports from University of Madras describe recent advances in hepatitis B virus
August 13th, 2008
In this recent study, researchers in Chennai, India conducted a study "To investigate the cellular defects by analyzing the (Th1/Th2) cytokine levels in vaccine responders and non-responders. Peripheral blood mononuclear cell (PBMC) from responders and non-responders were stimulated with or with out recombinant HBsAg or PHA." "Broad spectrum of cytokines viz (Th1) IFN-gamma, IL-2, TNF-alpha, IL-12 and (Th2) IL-10, IL-4 were measured after in vitro stimulation with recombinant HBsAg and were compared with respective antibody titers. A significant decrease (P = 0.001) in Th1 and Th2 cytokines namely, IL-2, INF-gamma, TNF-alpha and IL-10 in non-responders was observed. The...
Source: Vaccine Weekly (2008-08-13)
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