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HIV/AIDS
Researchers from Emory University, Emory Vaccine Center provide details of new studies and findings in the area of HIV/AIDS
August 13th, 2008
"The membrane-spanning domain (MSD) of the human immunodeficiency virus type 1 (HIV-1) gp41 glyco-protein is critical for its biological activity. Previous C-terminal truncation studies have predicted an almost invariant core structure of 12 amino acid residues flanked by basic amino acids in the HTV-1 MSD that function to anchor the glycoprotein in the lipid bilayer," researchers in the United States report. "To further understand the role of specific amino acids within the MSD core, we initially replaced the core region with 12 leucine residues and then constructed recovery-of-function mutants in which specific amino acid residues (including a GGXXG motif) were...
Source: Vaccine Weekly (2008-08-13)
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