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HIV/AIDS
Studies from Emory University, Emory Vaccine Center reveal new findings on HIV/AIDS
August 13th, 2008
"The membrane-proximal external region (MPER; K(665)WASLWNWFNITNWLWYIK(683)) of the human immunodeficiency virus type 1 (HIV-1) gp41 ectodomain plays a critical role in envelope glycoprotein-mediated fusion. In addition, the epitopes of important neutralizing antibodies (2175, Z13, and 4E10) and the sequence of the peptide fusion inhibitor T20 overlap this conserved region," scientists in the United States report. "The MPER has an unusually high percentage of tryptophan residues that likely contribute to the membrane-disrupting nature of the region, which is predicted to adopt an alpha-helical conformation on membrane contact. We have investigated the...
Source: Vaccine Weekly (2008-08-13)
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