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DNA Vaccines
Data from Harvard University provide new insights into DNA vaccines
August 13th, 2008
"In vivo electroporation (EP) has been shown to augment the immunogenicity of plasmid DNA vaccines, but its mechanism of action has not been fully characterized. In this study, we show that in vivo EP augmented cellular and humoral immune responses to a human immunodeficiency virus type I Env DNA vaccine in mice and allowed a 10-fold reduction in vaccine dose," scientists in the United States report. "This enhancement was durable for over 6 months, and re-exposure to antigen resulted in anamnestic effector and central memory CD8(+) T-lymphocyte responses. Interestingly, in vivo EP also recruited large mixed cellular inflammatory infiltrates to the site of inoculation....
Source: Vaccine Weekly (2008-08-13)
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