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Wellcome Trust Sanger Institute
Defining DNA differences to track and tackle typhoid
August 13th, 2008
For the first time, next-generation DNA sequencing technologies have been turned on typhoid fever - a disease that kills 600,000 people each year. The results will help to improve diagnosis, tracking of disease spread and could help to design new strategies for vaccination. The study sets a new standard for analysing the evolution and spread of a disease-causing bacterium: it is the first study of multiple samples of any bacterial pathogen at this level of detail. It uncovers previously hidden genetic signatures of the evolution of individual lineages of Salmonella Typhi. The team developed methods that are being used to type outbreaks, allowing...
Source: Vaccine Weekly (2008-08-13)
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