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Vaccine Weekly

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Wasting Disease



Findings from New York University in wasting disease reported



August 20th, 2008

"Significant outbreaks of prion disease linked to oral exposure of the prion agent have occurred in animal and human populations. These disorders are associated with a conformational change of a normal protein, PrPc (C for cellular), to a toxic and infectious form, PrPsc (Sc for scrapie)," scientists in the United States report.

"None of the prionoses currently have an effective treatment. Some forms of prion disease are thought to be spread by oral ingestion of PrPsc, such as chronic wasting disease and variant Creutzfeldt-Jakob disease. Attempts to obtain an active immunization in wild-type animals have been hampered by auto-tolerance to PrP and potential toxicity....


Source: Vaccine Weekly (2008-08-20)

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