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Flu Vaccines
Investigators at University of Pennsylvania, Medical Department zero in on flu vaccines
August 20th, 2008
"Receipt of an A/NJ/1976/H1N1 ''swine flu'' vaccine in 1976, unlike receipt of influenza vaccines used in subsequent years, was strongly associated with the development of the neurologic disorder Guillain-Barre syndrome (GBS). Anti-ganglioside antibodies (e. g., anti-GM(1)) are associated with the development of GBS, and we hypothesized that the swine flu vaccine contained contaminating moieties (such as Campylobacter jejuni antigens that mimic human gangliosides or other vaccine components) that elicited an anti-GM(1) antibody response in susceptible recipients. Surviving samples of monovalent and bivalent 1976 vaccine, comprising those from 3 manufacturers and 11 lot numbers, along with...
Source: Vaccine Weekly (2008-08-20)
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