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Vaccines
Researchers from University of North Carolina publish findings in vaccines
August 20th, 2008
"Two key routes of Francisella tularensis infection are through the skin and airway. We wished to understand how the route of inoculation influenced the primary acute adaptive immune response," scientists writing in the journal Infection and Immunity report. "We show that an intranasal inoculation of the F. tularensis live vaccine strain (LVS) with a 1,000-fold-smaller dose than an intradermal dose results in similar growth kinetics and peak bacterial burdens. In spite of similar bacterial burdens, we demonstrate a difference in the quality, magnitude, and kinetics of the primary acute T-cell response depending on the route of inoculation. Further, we show that...
Source: Vaccine Weekly (2008-08-20)
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