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Enzyme Research
Research from Charles University, Medical Faculty provides new data on enzyme research
August 20th, 2008
A report, 'Lytic infection with vaccinia virus activates caspases in a Bcl-2-inhibitable manner,' is newly published data in Virus Research. "Vaccinia virus (VV) is considered to cause lytic infection of most cells, with lysis being regarded equivalent to necrosis. Activation of caspases has not been associated with necrosis," scientists in Prague, Czech Republic report. "However, we observed the activation and activity of caspases in epithelial cells HeLa G and BSC-40 lytically infected with VV. Using three different flow-cytometric approaches, we characterized the distinct stages of caspase cascade in VV-infected cells: a cleaved, activated form of caspases...
Source: Vaccine Weekly (2008-08-20)
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