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Falciparum Malaria
Reports from E.J. Remarque and co-researchers add new data to research in falciparum malaria
August 20th, 2008
"Plasmodium falciparum apical membrane antigen 1 (PfAMA1), a candidate malaria vaccine, is polymorphic. This polymorphism is believed to be generated predominantly tinder immune selection pressure and, as a result, may compromise attempts at vaccination," investigators in Netherlands report. "Alignment of 355 PfAMA1 sequences shows that around 10% of the 622 amino acid residues can vary between alleles and that linkages between polymorphic residues occur. Using this analysis, we have designed three diversity-covering (DiCo) PfAMA1 sequences that take account of these linkages and, when taken together, on average incorporate 97% of amino acid variability observed. For...
Source: Vaccine Weekly (2008-08-20)
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