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Life Sciences
Studies from B. Mattioli and colleagues reveal new findings on life sciences
August 27th, 2008
According to recent research published in the Faseb Journal, "Leptin is an adipocyte-derived hormone/cytokine that links nutrition, metabolism, and immune homeostasis and is endowed to modulate several immune responses. We previously demonstrated that both immature and mature human dendritic cells (DCs) express a functional leptin receptor, and we found that leptin activates DCs, licenses them for Th1 priming, and promotes DC survival." "Moreover, we found that leptin induces rearrangement of actin microfilaments, leading to uropod and ruffle formation. Here we monitor the effects of leptin on DC migratory capacities, focusing on the intracellular signaling...
Source: Vaccine Weekly (2008-08-27)
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