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Tuberculosis
New findings reported from McMaster University describe advances in tuberculosis
August 27th, 2008
"Pulmonary tuberculosis (TB) remains a serious health problem worldwide. Effective vaccination strategies are needed," scientists writing in the journal Molecular Therapy report. "We report the development of a novel TB vaccine using vesicular stomatitis virus (VSV) as a viral vector system to express Ag85A. VSVAg85A was shown to be immunogenic when given to mice by either an intranasal or an intramuscular (IM) route. Although distinct T-cell profiles resulted from both routes of immunization, only intranasal delivery generated a mucosal T-cell response that was protective upon pulmonary Mycobacterium tuberculosis (M. tb) challenge. While this protection...
Source: Vaccine Weekly (2008-08-27)
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