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Hepatitis C Virus
New findings from University of Washington, Medical Department in the area of hepatitis C virus published
August 27th, 2008
"Innate immune defences are essential for the control of virus infection and are triggered through host recognition of viral macromolecular motifs known as pathogen-associated molecular patterns (PAMPs)(1). Hepatitis C virus (HCV) is an RNA virus that replicates in the liver, and infects 200 million people worldwide(2)," scientists writing in the journal Nature report. "Infection is regulated by hepatic immune defences triggered by the cellular RIG-I helicase. RIG-I binds PAMP RNA and signals interferon regulatory factor 3 activation to induce the expression of interferon-alpha/beta and antiviral/interferon-stimulated genes (ISGs) that limit infection(3-10). Here...
Source: Vaccine Weekly (2008-08-27)
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