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Stomatitis
Research from D.S. Green et al broadens understanding of stomatitis
September 3rd, 2008
"A majority of adults without evidence of exposure to vesicular stomatitis virus (VSV) have serum IgG antibodies that interact with pro-inflammatory TLR7 in the presence of VSV, and enhance several aspects of VSV-induced IFN-alpha production," scientists in the United States report. "Enhancing IgG antibody enables human PBMC to make IFN-a more rapidly and in higher titers in response to a broad range of VSV-concentrations that include those too low to independently stimulate IFN-alpha production. These antibodymediated functions compensate for the inherent delay in virus-induced IFN-alpha production in vitro, and have the potential to improve the in vivo IFN-a response...
Source: Vaccine Weekly (2008-09-03)
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