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Vaccine Weekly

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Vaccine Efficacy



Reports from University of Witwatersrand highlight recent research in vaccine efficacy



September 3rd, 2008

According to recent research from Johannesburg, South Africa, "This article discusses lessons learned from clinical trials with pneumococcal conjugate vaccines (PCVs). A review of major clinical trials investigating PCV efficacy, this article provides the context to explore challenges associated with studying pneumococcal pneumonia and vaccine efficacy, particularly related to non-bacteremic disease, serotypes, and radiograph interpretation."

"Throughout these clinical trials, improving the pneumonia diagnosis specificity increased vaccine efficacy estimates. Additional analysis suggests this improvement may come at a cost of detecting much less of the disease burden,"...


Source: Vaccine Weekly (2008-09-03)

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