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Hookworm Disease Vaccines
Studies from Queensland University of Technology yield new data on hookworm disease vaccines
September 3rd, 2008
Investigators publish new data in the report 'A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus.' "mRNAs encoding cathepsin B-like cysteine proteases (CatBs) are abundantly expressed in the genomes of blood-feeding nematodes. Recombinant CatBs have been partially efficacious in vaccine trials in animal models of hookworm infection, supporting further investigation of these enzymes as new control tools," scientists writing in the journal Molecular and Biochemical Parasitology report. "We recently described a family of four distinct CatBs (Na-CP-2, -3, -4, -5) from the human hookworm, Necator americanus. Here...
Source: Vaccine Weekly (2008-09-03)
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