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Allergies
Researchers at National Institute of Allergy and Infectious Diseases release new data on allergies
September 3rd, 2008
"Immunization with the highly polymorphic Plasmodium falciparum apical membrane antigen 1 (PfAMA1) induces protection in animals but primarily against parasites that express the same or similar alleles. One strategy to overcome the obstacle of polymorphism is to combine PfAMA1 proteins representing major haplotypes into one vaccine," scientists in the United States report. "To determine the minimum number of haplotypes that would confer broad protection, we sequenced the coding region of PfAMA 1 from 97 clones from around the world and 61 isolates from Mali, identifying 150 haplotypes for domains 1 to 3 that included previous sequences. A clustering algorithm grouped...
Source: Vaccine Weekly (2008-09-03)
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