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Vaccinia Virus
New vaccinia virus study results reported from University of Florida
September 10th, 2008
According to a study from the United States, "The emergence of drug resistant viruses, together with the possibility of increased virulence, is an important concern in the development of new antiviral compounds. Cidofovir (CDV) is a phosphonate nucleotide that is approved for use against cytomegalovirus retinitis and for the emergency treatment of smallpox or complications following vaccination." "One mode of action for CDV has been demonstrated to be the inhibition of the viral DNA polymerase. We have isolated several CDV resistant (CDVR) vaccinia viruses through a one step process, two of which have unique single mutations within the DNA polymerase. An additional...
Source: Vaccine Weekly (2008-09-10)
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