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Immunization
Data on immunization detailed by researchers at University of Bonn, Institute for Molecular Medicine
September 10th, 2008
New research, 'CD11c: not merely a murine DC marker, but also a useful vaccination target,' is the subject of a report. According to recent research from Bonn, Germany, "The induction of robust CD4(+) and CD8(+) T cell responses is a central aim in antiviral and anticancer vaccination. To this end, dendritic cells (DC) need to capture the vaccine, process and present it on MHC class I and II molecules." "The mechanisms by which DC acquire antigen predetermine the quantity and quality of the ensuing T cell activation. In this issue of the European Journal of Immunology, it is demonstrated that targeting antigen towards CD11c, an integrin expressed preferentially by...
Source: Vaccine Weekly (2008-09-10)
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