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DNA Vaccines
Data on DNA vaccines described by F.S. Kano et al
September 10th, 2008
"The outer membrane proteins of Anaplasma marginale have been the focus of research to obtain an improved vaccine against bovine anaplasmosis. We evaluated the capacity of the recombinant plasmids pcDNA-msplce, pcDNA-msplo, and pcDNA-mp5 to express MSP1a, MSP1b, and MSP5 proteins, and to determine the immunogenicity of BALB/c mice immunized with these plasmids individually or in association," researchers in Londrina, Brazil report. "Expression of proteins was confirmed in Vero cells by IFA.The combination of recombinant plasmids showed high antibodies response, produced better induction of Thl response than individual plasmids, and induced significant proliferation of...
Source: Vaccine Weekly (2008-09-10)
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