Cancer Vaccines

Reports outline cancer vaccines study results from University of Pittsburgh

Published in Vaccine Weekly, September 10th, 2008

According to recent research from the United States, "Preferential activation of regulatory T (Treg) cells limits autoinumme tissue damage during chronic immune responses but can also facilitate tumor growth. Here, we show that tissue-produced inflammatory mediators prime maturing dendritic cells (DC) for the differential ability of attracting anti-inflammatory Treg cells."

"Our data show that prostaglandin E-2 (PGE(2)), a factor overproduced in chronic inflammation and cancer, induces stable Treg-attracting properties in maturing DC, mediated by CCL22. The elevated production of CCL22 by PGE(2)-matured DC persists after the removal of PGE(2) and is further elevated...

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Source: Vaccine Weekly (2008-09-10)

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