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Drug Resistance
Study data from University of Alberta update understanding of drug resistance
September 10th, 2008
According to recent research published in the Journal of Virology, "Vaccinia virus replication is inhibited by etoposide and mitoxantrone even though poxviruses do not encode the type II topoisomerases that are the specific targets of these drugs. Furthermore, one can isolate drug-resistant virus carrying mutations in the viral DNA ligase and yet the ligase is not known to exhibit sensitivity to these drugs." "A yeast two-hybrid screen was used to search for proteins binding to vaccinia ligase, and one of the nine proteins identified comprised a portion (residue 901 to end) of human topoisomerase II beta. One can prevent the interaction by introducing a C-11-to-Y...
Source: Vaccine Weekly (2008-09-10)
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