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HIV/AIDS
Studies in the area of HIV/AIDS reported from Harvard University
September 10th, 2008
According to recent research published in the journal AIDS, "Selection of specific human leukocyte antigen (HLA)-restricted cytotoxic T-lymphocyte (CTL) escape mutations in key Gag epitopes has been associated with loss of HIV immune control on an individual basis. Here we undertake a population-based identification of HLA-associated polymorphisms in Gag and investigate their relationship with plasma viral load." "Cross-sectional analysis of 567 chronically HIV subtype B-infected, treatment-naive individuals. HLA class I-associated Gag substitutions were identified using phylogenetically corrected analysis methods featuring a multivariate adjustment for HLA...
Source: Vaccine Weekly (2008-09-10)
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