Hepatitis C Virus

Research from Z.Y. Keck and co-authors yields new data on hepatitis C virus

Published in Vaccine Weekly, September 10th, 2008

"A challenge in hepatitis C virus (HCV) vaccine development is defining conserved protective epitopes. A cluster of these epitopes comprises an immunodominant domain on the E2 glycoprotein, designated domain B. CBH-2 is a neutralizing human monoclonal antibody to a domain B epitope that is highly conserved," investigators in the United States report.

"Alanine scanning demonstrated that the epitope involves residues G523, G530, and D535 that are also contact residues for E2 binding to CD81, a coreceptor required for virus entry into cells. However, another residue, located at position 431 and thus at a considerable distance in the linear sequence of E2, also contributes...

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Source: Vaccine Weekly (2008-09-10)

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