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Lymphopenia
Research results from Emory University, Emory Vaccine Center update understanding of lymphopenia
September 17th, 2008
According to recent research from the United States, "For a wide variety of microbial pathogens, the outcome of the infection is indeterminate. In some individuals the microbe is cleared, but in others it establishes a chronic infection, and the factors that tip this balance are often unknown." "In a widely used model of chronic viral infection, C57BL/6 mice clear the Armstrong strain of lymphocytic choriomeningitis virus (LCMV), but the clone 13 strain persists(1,2). Here we show that the Armstrong strain induces a profound lymphopenia at days 1-3 after infection, but the clone 13 strain does not. If we transiently augment lymphopenia by treating the clone-13-infected...
Source: Vaccine Weekly (2008-09-17)
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