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Life Sciences
Research from Duke University in life sciences provides new insights
September 17th, 2008
"CD4+CD25'''9''FoxP3+ regulatory T (Treg) cells limit antigen-specific immune responses and are a cause of suppressed anticancer immunity. In preclinical and clinical studies, we assessed the immune consequences of FoxP3+ Treg-cell depletion in patients with advanced malignancies," scientists in the United States report. "We demonstrated that a CD25'''9'' targeting immunotoxin (denileukin diftitox) depleted FoxP3+ Treg cells, decreased Treg-cell function, and enhanced antigen-specific T-cell responses in vitro. We then attempted to enhance antitumor immune responses in patients with carcinoembryonic antigen (CEA)-expressing malignancies by Treg-cell depletion. In a...
Source: Vaccine Weekly (2008-09-17)
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