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Vaccine Weekly

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Tuberculosis



Research results from University of Toulouse update knowledge of tuberculosis



September 17th, 2008

"Pathogenic mycobacteria such as Mycobacterium tuberculosis, the causative agent of tuberculosis, are surrounded by a noncovalently bound capsule, whose major carbohydrate constituent is a glycogen-like alpha-glucan. In the present study we compared the structures of the extracellular polysaccharide to that of the ubiquitous intracellular glycogen," scientists in Toulouse, France report.

"The alpha-glucan was isolated from the culture medium of Mycobacterium bovis Bacille Calmette Guerin, the vaccine strain, in which it is released whereas the intracellular glycogen was obtained after the disruption of cells. The two purified polysaccharides were eluted from permeation...


Source: Vaccine Weekly (2008-09-17)

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