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Virology
Research from University of Alabama provides new data on virology
September 17th, 2008
"In a study of 114 epidemiologically linked Zambian transmission pairs, we evaluated the impact of human leukocyte antigen class I (HLA-I)-associated amino acid polymorphisms, presumed to reflect cytotoxic T lymphocyte (CTL) escape in Gag and Nef of the virus transmitted from the chronically infected donor, on the plasma viral load (VL) in matched recipients 6 mo after infection. CTL escape mutations in Gag and Nef were seen in the donors, which were subsequently transmitted to recipients, largely unchanged soon after infection," scientists writing in the Journal of Experimental Medicine report. "We observed a significant correlation between the number of Gag...
Source: Vaccine Weekly (2008-09-17)
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