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Dengue Fever Vaccines
Study data from National Institute of Allergy and Infectious Disease update understanding of dengue fever vaccines
September 17th, 2008
Data detailed in 'Evaluation of St. Louis encephalitis virus/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeys' have been presented. According to a study from the United States, "To develop a live attenuated virus vaccine against St. Louis encephalitis (SLE) virus, two antigenic chimeric viruses were generated by replacing the membrane precursor and envelope protein genes of dengue virus type 4 (DEN4) with those from SLE with or without a 30 nucleotide deletion in the DEN4 3' untranslated region of the chimeric genome." "Chimeric viruses were compared with parental wild-type SLE for level of neurovirulence and neuroinvasiveness in mice and for...
Source: Vaccine Weekly (2008-09-17)
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