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Vaccine Weekly

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Life Sciences



Researchers at Washington University, Medical Department have published new data on life sciences



September 24th, 2008

According to recent research from the United States, "Studies directed at vaccine development and mucosal immunity against Streptococcus pyogenes would benefit from the availability of live attenuated strains. Our approach for production of candidate live attenuated strains was to identify mutations that did not alter growth in vitro and did not alter the overall complement of virulence factors produced but did result in reduced levels of expression of multiple secreted virulence factors."

"A global reduction but not elimination of expression would likely lead to attenuation while maximizing the number of antigenic targets available for stimulation of immunity....


Source: Vaccine Weekly (2008-09-24)

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