NIH/National Institute of Allergy and Infectious Diseases

Study reveals link between Apobec3 gene and neutralizing antibody response to retrovirus

Published in Vaccine Weekly, September 24th, 2008

Scientists have uncovered new evidence that strengthens the link between a host-cell gene called Apobec3 and the production of neutralizing antibodies to retroviruses. Published in the Sept. 5 issue of Science, the finding adds a new dimension to the set of possible explanations for why most people who are infected with HIV do not make neutralizing antibodies that effectively fight the virus.

Antibodies are key to warding off viral infections, and most vaccines against viral diseases stimulate the body to make antibodies against the target virus. Yet no one knows how to make a vaccine that artificially stimulates the production of antibodies that can readily neutralize...

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Source: Vaccine Weekly (2008-09-24)

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