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Vaccines
Studies in the area of vaccines reported from Birkbeck College
September 24th, 2008
A report, 'Are bacterial vaccine antigens T-cell epitope depleted,' is newly published data in Trends In Immunology. "For many infectious diseases, protective immunity can be elicited by vaccination with pathogen-derived proteins. Peptides derived from these proteins are bound to major histocompatibility complex (MHC) molecules and presented to T-cell receptors to stimulate an immune response," investigators in London, the United Kingdom report. "We show here that, paradoxically, bacterial proteins known experimentally to elicit a protective immune response are relatively depleted in peptides predicted to bind to human MHC alleles. We propose three nonconflicting...
Source: Vaccine Weekly (2008-09-24)
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