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Cholera
Studies from Harvard University, Medical Department reveal new findings on cholera
September 24th, 2008
"Defined mutant libraries allow for efficient genome-scale screening and provide a convenient collection of mutations in almost any nonessential gene of interest. Here, we present a near-saturating transposon insertion library in Vibrio cholerae strain C6706, a clinical isolate belonging to the 01 El Tor biotype responsible for the current cholera pandemic," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report. "Automated sequencing analysis of 23,312 mutants allowed us to build a 3,156-member subset library containing a representative insertion in every disrupted ORF. Because uncharacterized...
Source: Vaccine Weekly (2008-09-24)
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