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Immunotherapy
Researchers from Medical University of Vienna describe findings in immunotherapy
September 24th, 2008
"Allergen-specific immunotherapy is currently based on the administration of allergen extracts containing natural allergens. However, its broad application is limited by the poor quality of these extracts," researchers in Vienna, Austria report. "Based on recombinant allergens, well-defined allergy vaccines for allergen-specific immunotherapy can be produced. Furthermore, they can be modified to reduce their allergenic activity and to avoid IgE-Mediated side effects. Here, we demonstrate that the immunogenicity of two grass pollen-derived hypoallergenic allergen derivatives could be increased by engineering them as a single hybrid molecule. We used a hypoallergenic PhI...
Source: Vaccine Weekly (2008-09-24)
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