Life Sciences
Researchers at Franklin University target life sciences
Published in Vaccine Weekly, October 1st, 2008
"Inherent deficiencies of Leishmania in heme biosynthesis were genetically complemented for delta-amino-levulinate-inducible biosynthesis and accumulation of light-excitable uroporphyrin. The phototoxic flagellar immobilization and cytolysis phenotypes and porphyrin mobilization noted previously were further analyzed biochemically and cytologically to delineate the mechanism of phototoxicity and detoxification in this monoporphyric model," scientists writing in the journal Eukaryotic Cell report.
"Under optimal conditions of induction for approximately 3 days, cells remained viable but became increasingly uroporphyric, peaking at >= 90% of the population by...
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Source: Vaccine Weekly (2008-10-01)
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