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Hypertrophy
Recent findings in hypertrophy described by Y.Y. Liu and colleagues
October 1st, 2008
"Hypertension-induced cardiovascular hypertrophy and fibrosis are critical in the development of heart failure. The activity of TLRs has been found to be involved in the development of pressure overload-induced myocardial hypertrophy and cardiac fibrosis," researchers in Beijing, People's Republic of China report. "We wondered whether vaccine bacillus Calmette-Guerin (BCG), which activated TLR4 to elicit immune responses, modulated the pressure overload-stimulated cardiovascular hypertrophy and cardiac fibrosis in the murine models of abdominal aortic constriction (AAC)-induced hypertension. Before or after AAC, animals received BCG, TLR4 agonist, IFN-gamma, or TLR4...
Source: Vaccine Weekly (2008-10-01)
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