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Respiratory Syncytial Virus Vaccines



New respiratory syncytial virus vaccines research from National Institute of Allergy and Infectious Disease outlined



October 1st, 2008

Investigators publish new data in the report 'Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.' "Severe illness, type 2 cytokine production, and pulmonary eosinophilia are adverse immune responses resulting from respiratory syncytial virus (RSV) challenge of vvGs-immunized mice. We have shown IL-4 and IL-13 activity must be simultaneously inhibited to reduce disease severity," scientists in the United States report.

"We now address the contributions of IL-5, eotaxin-1, and CD4+ and CD8+ T cells to the induction of disease-enhancing immune responses. Depletion of CD4+ T cells...


Source: Vaccine Weekly (2008-10-01)

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