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DNA Vaccines
Study findings on DNA vaccines are outlined in reports from Wyeth
October 8th, 2008
New investigation results, 'Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines,' are detailed in a study published in Vaccine. According to a study from the United States, "The effectiveness of plasmid DNA (pDNA) vaccines can be improved by the co-delivery of plasmid-encoded molecular adjuvants. We evaluated pDNAs encoding GM-CSF, Flt-3L, IL-12 alone, or in combination, for their relative ability to serve as adjuvants to augment humoral and cell-mediated immune responses elicited by prototype pDNA vaccines." "In Balb/c mice we found that co-administration of plasmid-based murine GM-CSF...
Source: Vaccine Weekly (2008-10-08)
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