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Antisense Technology
Researchers at Arizona State University have published new data on antisense technology
October 8th, 2008
"We have devised and constructed a biological containment system designed to cause programmed bacterial cell lysis with no survivors. We have validated this system, using Salmonella enterica, serovar Typhimurium vaccines for antigen delivery after colonization of host lymphoid tissues," investigators in the United States report. "The system is composed of two parts. The first component is Salmonella typhimurium strain chi 8937, with deletions of asdA and arabinose-regulated expression of murA, two genes required for peptidoglycan synthesis and additional mutations to enhance complete lysis and antigen delivery. The second component is plasmid pYA3681, which encodes...
Source: Vaccine Weekly (2008-10-08)
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