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West Nile Virus
Research on west nile virus detailed by scientists at University of Texas
October 8th, 2008
According to recent research from the United States, "Existing live-attenuated flavivirus vaccines (LAV) could be improved by reducing their potential to recombine with naturally circulating viruses in the field. Since the highly conserved cyclization sequences (CS) found in the termini of flavivirus genomes must be complementary to each other to support genome replication, we set out to identify paired mutant CS that could support the efficient replication of LAV but would be unable to support replication in recombinant viruses harboring one wild-type (WT) CS." "By systematic evaluation of paired mutated CS encoded in West Nile virus (WNV) replicons, we identified...
Source: Vaccine Weekly (2008-10-08)
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