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Encephalomyelitis
Study results from Montana State University broaden understanding of encephalomyelitis
October 15th, 2008
According to a study from the United States, "Treatment with an anti-inflammatory Salmonella vaccine expressing enterotoxigenic Escherichia coli colonization factor Ag 1 (CFA/I) proved effective in stimulating protective, potent CD25(+)CD4(+) regulatory T (T-g) cells in susceptible mice challenged with experimental autoimmune encephalomyelitis (EAE). Because the Salmonella vector was considerably less protective, we questioned whether altering fimbrial subunit expression to resemble conventional Salmonella expression may impact T-reg cell potency." "The Salmonella-CFA/I vaccine was modified to limit fimbrial subunit expression to the intracellular compartment...
Source: Vaccine Weekly (2008-10-15)
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