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HIV/AIDS
Research on HIV/AIDS published by scientists at St. George's University
October 15th, 2008
According to recent research from London, the United Kingdom, "The mechanisms by which HIV-1 induces chronic pathogenic immune activation associated with disease progression remain unclear despite many years of AIDS research. One proposal suggests that sequence and structural mimicry between gp120 and HLA may endow HIV with the capacity to arouse alloreactive and autoimmune responses within the susceptible host, fueling disease progression in a manner similar to graft-versus-host disease (GVHD)." "Both gp120 and HLA share a common functional interaction with CD4 but also demonstrate peptide binding properties. Here we report the conserved nature of this feature across...
Source: Vaccine Weekly (2008-10-15)
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