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Autoimmune Disease
New autoimmune disease study findings have been reported by scientists at University Hospital
October 15th, 2008
According to a study from Erlangen, Germany, "Dendritic cells (DCs) are currently considered as promising tools for vaccination against tumors and also autoimmune responses. A major point of concern has been the use of fetal calf serum (FCS) as a source of heterologous antigen in DC cultures." "FCS peptides can be presented by the DCs and cause T-cell responses in the recipient. We investigated the role of FCS in an autoimmune model where DC injections can prevent peptide-specifically from experimental autoimmune encephalomyelitis (EAE). We show that murine bone marrow-derived DCs generated in FCS-containing or serum-free media resulting in a similar phenotype,...
Source: Vaccine Weekly (2008-10-15)
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