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HIV/AIDS
Researchers from Merck & Company, Inc. discuss findings in HIV/AIDS
October 22nd, 2008
"Results from Merck's phase II adenovirus type 5 (Ad5) gag/pol/nef test-of-concept trial showed that the vaccine lacked efficacy against human immunodeficiency virus (HIV) infection in a high-risk population. Among the many questions to be explored following this outcome are whether (i) the Ad5 vaccine induced the quality of T-cell responses necessary for efficacy and (ii) the lack of efficacy in the Ad5 vaccine can be generalized to other vector approaches intended to induce HIV type 1 (HIV-1)-specific T-cell responses," scientists in the United States report. "Here we present a comprehensive evaluation of the T-cell response profiles from cohorts of clinical trial...
Source: Vaccine Weekly (2008-10-22)
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