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Vaccines
Study findings from Anderson University, Medical Department broaden understanding of vaccines
October 22nd, 2008
"Francisella tularensis is a zoonotic bacterium that must exist in diverse environments ranging from arthropod vectors to mammalian hosts. To better understand how virulence genes are regulated in these different environments, a transcriptional response regulator gene ( genome locus FTL0552) was deleted in F. tularensis live vaccine strain (LVS)," scientists in the United States report. "The FTL0552 deletion mutant exhibited slightly reduced rates of extracellular growth but was unable to replicate or survive in mouse macrophages and was avirulent in the mouse model using either BALB/c or C57BL/6 mice. Mice infected with the FTL0552 mutant produced reduced levels of...
Source: Vaccine Weekly (2008-10-22)
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