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Vaccinia Virus
Investigators at Trinity College zero in on vaccinia virus
October 22nd, 2008
"Viruses are detected by different classes of pattern recognition receptors (PRRs), such as Toll-like receptors and RIG-like helicases. Engagement of PRRs leads to activation of interferon (IFN)-regulatory factor 3 (IRF3) and IRF7 through IKK epsilon and TBK1 and consequently IFN-beta induction," scientists writing in the Embo Journal report. "Vaccinia virus (VACV) encodes proteins that manipulate host signalling, sometimes by targeting uncharacterised proteins. Here, we describe a novel VACV protein, K7, which can inhibit PRR-induced IFN-beta induction by preventing TBK1/IKK epsilon-mediated IRF activation. We identified DEAD box protein 3 (DDX3) as a host...
Source: Vaccine Weekly (2008-10-22)
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