Vaccinia Virus

Research reports on vaccinia virus from C.Y. Huang and colleagues provide new insights

Published in Vaccine Weekly, October 22nd, 2008

According to a study from Taipei, Taiwan, "Vaccinia virus is a large DNA virus that infects many cell cultures in vitro and animal species in vivo. Although it has been used widely as a vaccine, its cell entry pathway remains unclear."

"In this study, we showed that vaccinia virus intracellular mature virions bound to the filopodia of HeLa cells and moved toward the cell body and entered the cell through an endocytic route that required a dynamin-mediated pathway but not a clathrin- or caveola-mediated pathway. Moreover, virus penetration required a novel cellular protein, vaccinia virus penetration factor (NTEF). VPEF was detected on cell surface lipid rafts and on...

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Source: Vaccine Weekly (2008-10-22)

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