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Enzyme Research
Study results from University of Otago provide new insights into enzyme research
October 29th, 2008
"F-box proteins direct the degradation of an extensive range of proteins via the ubiquitin-proteasome system. Members of this large family of proteins are typically bipartite," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report. "They recruit specific substrates through a substrate-binding domain and, via the F-box, link these to core components of a major class of ubiquitin ligases (SCF1). F-box proteins thus determine the specificity of SCF1-mediated ubiquitination. F-box-like motifs were recently detected in poxvirus ankyrin repeat (ANK) proteins but clear compositional differences to...
Source: Vaccine Weekly (2008-10-29)
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