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Gene Therapy
New gene therapy data have been reported by scientists at Shanghai Jiao Tong University
October 29th, 2008
According to a study from Shanghai, People's Republic of China, "Although antibodies (Abs) produced by B cells can treat cancer in certain models, T cells have been accountable for the major effector to control cancer. Immune recognition toward tyrosinase-related protein-1 (TRP-1), a melanoma associated antigen up-regulated on the surface of B16F10 melanomas, generally leads to tumor protection mediated by Abs." "In this study, immunization with dendritic cells ex vivo transduced with adenovirus encoding TRP-1 stimulates immune activation and potent tumor protection mediated by CD8 T cells in the absence of autoimmune consequence. Transfer of CD8 T cells from immunized...
Source: Vaccine Weekly (2008-10-29)
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